) ( ) min) (nl/gl/min) RatioRatio ( Handle Mean)FEVCulture ResultsF M F M M Fno mutations ???????????1 1 1 four two 161 46 42 45 35 3257 46 41 45 35 3293 100 98 one hundred one hundred one hundred 99632.53 eight.47 3.23 4.75 7.35 five.69 five.362.0.538 2.713 0.715 0.606 1.285 1.426 1.260.0.221 0.376 0.244 0.139 0.338 0.272 0.83.49 142.02 92.03 52.49 127.56 102.42 100632????????????C Mean six SD or sumsR Heterozygotes Hz1 Hz2 Hz3 Hz4 M F M F F508del 3659 del C F508del R553X or N1303K ????three 1 1 137 19 17 3537 18 17 33100 95 one hundred 94 97632.76 1.63 11.95 3.14 4.964.0.462 0.215 1.704 0.196 0.6460.0.188 0.139 0.150 0.062 0.71.00 52.26 56.66 23.41 51620????????Hz Mean six SD or sumsR CF-Pancreatic Insufficient PI1 PI2 PI3 PI4 PI5 PI6 PI7 PI8 PI9 PI10 PI11 PI12 F F F F F F M M M F F F F508del/F508del F508del/3659 del C F508del/F508del F508del/I1027T/R851X R553X/N1303K F508/F508 F508/621+1G-.T F508del/F508del F508/G551D F508del/G551D F508del/G551D F508del/G551D one hundred 82 70 ?80 91 133 116 ?110 102 781 three 1 three 3 three 1 two 2 1 1 131 27 34 47 48 73 26 94 82 124 97 1230 0 0 0 0 0 0 29 0 0 0 00 0 0 0 0 0 0 31 0 0 0 0 360.12.52 3.35 0.88 2.65 1.58 1.35 4.96 two.11 4.31 0.85 1.90 2.14 2.461.0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000 0.000 0.000 0.0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.005 0.000 0.000 0.000 0.000 0.0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.90 0.00 0.00 0.00 0.00 0.1660.0170 103 88 ?Tx 64 95 44 ?98 87 51Pa (mucoid) Aspergillus only MRSA, Pa (mucoid) ?Tx Pa (mucoid) Pa (muc.,nonmuc.) Pa (muc.,nonmuc.) ?Pa/SA61 only 12/10 Staph. Aureas Pa (non-muc.), MRSACFPI Mean six SD or sumsR CF-Pancreatic Enough PS1 PS2 PS4 PS5 PS6 F M F M FF508del/3849+10 kbCRT 65 F508del/R117H, 5T F508del/3849+10 kb CRT F508del/R117H F508del/3849+10 kb CRT 92.five 90 83 702 2 two three 343 38 59 51 370 0 2 0 00 0 three 0 0 11.01 2.16 2.42 four.20 1.23 two.261.0.000 0.000 0.000 0.000 0.000 0.0.000 0.000 0.000 0.000 0.000 0.0.00 0.00 0.00 0.00 0.00 0.0041 ?51 66 38 49MRSA, Pa (muc.) ?MRSA, Pa (muc, non-m) Pa(muc and non), SA Pa (m)CFPS Mean six SD or sumsR CFTR-Related R1 R2 R3 R4 M F F M F508del/F1052V, nv 7T/9T M470V M470V, 7T/7T F508del/Unk69 44 712 three 340 57 3440 57 13100 100 38 646.3-Fluoro-4-iodo-2-methoxypyridine site 76 2.Formula of Biotin-PEG1-NH2 88 1.87 four.0.265 0.620 0.010 0.0.038 0.211 0.004 0.14.16 79.65 1.52 1.98?81 ?44?A. xylosoxidans ?Pa (mucoid)PLOS A single | plosone.orgSingle Gland CFTR-Dependent Sweat AssayTable 1. Cont.IDGGenotypeSweat Cl (mEq)# TestsC glands/ MCh Cktl M MCh Rate Mean Glands Glands glands (nl/gl/ Cktl Rate C/M (n) (n) ( ) min) (nl/gl/min) Ratio 200 154 76630 3.862.6 0.226.28 0.Ratio ( Manage Mean) 24637FEV1 63Culture ResultsCFTR-R Imply six SD or sumsRGroups have been defined as follows: control; wholesome volunteers with no identified CF connection ne was unfavorable for many prevalent mutations through genotyping.PMID:24631563 Heterozygotes: parents or siblings of CF subjects; all confirmed via genotyping. The CFPI, CFPS and CFTR-R groupings had been assigned by the CF clinic at Stanford determined by clinical evaluations and genotyping. Variety of tests indicates tests analyzed for the data shown in following eight columns. Unavailable data indicated by “2”. Only adult subjects had been tested. One particular CF subject was tested ,1 year right after a lung transplant. Ratios were averaged for each gland’s response to MCh and cocktail to provide the imply b-cocktail/MCh (C/M) ratio. Either sums or indicates 6 S.D. are shown for chosen group measures. doi:ten.1371/journal.pone.0077114.tpositioned 1.7 cm above the skin to make extra diffuse light that wo.