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Modulation of Chicken Intestinal Immune Gene Expression by Modest Cationic Peptides as Feed Additives for the duration of the initial Week PosthatchMichael H. Kogut,a Kenneth J. Genovese,a Haiqi He,a Christina L. Swaggerty,a Yiwei JiangbUSDA-ARS, SPARC, College Station, Texas, USAa; My Galaxy LLC, Ft. Worth, Texas, USAbWe happen to be investigating modulation approaches tailored around the selective stimulation in the host’s immune system as an alternative to direct targeting of microbial pathogens by antibiotics. One particular such approach could be the use of a group of smaller cationic peptides (BT) developed by a Gram-positive soil bacterium, Brevibacillus texasporus. These peptides have immune modulatory properties that enhance both leukocyte functional efficiency and leukocyte proinflammatory cytokine and chemokine mRNA transcription activities in vitro. In addition, when supplied as a feed additive for just four days posthatch, BT peptides considerably induce a concentration-dependent protection against cecal and extraintestinal c.